products, calls. SM Study: Umbilical cord blood may transplant well blood-disease patients used in study The Washington Post Umbilical cord blood, normally discarded after the delivery of a newborn, may be an extremely useful source of cells needed in the treatment of people with leukemia and other serious blood diseases, according to new research. Cord blood transplantation appears to be as effective as, and safer than, bone marrow transplantation when there isn't a perfect genetic match between the donor of the cells and the person receiving then, physicians at Duke University Medical Center reported Wednesday. If the new findings are borne out by further research, this method of transplantation could help surmount a major obstacle many patients face the lack of suitable bone marrow donors. possibility that you can do transplants without complete matching, and with relative impunity, is a real advance," said Paul McCurdy, director of the blood resources program at the National Heart, Lung and Blood Institute (NHLBI), in Bethesda, Md.
The this fall will begin a fiveyear study of cord blood transplantation" at a half-dozen hospitals around the United States. Most people who need their blood system after treatment for cancer currently seek a bone marrow donation from a relative. (In some cases, a person's own bone marrow, once purged, of diseased cells, can be When a relative with a good genetic match is not available, the chance of finding a suitable match among the 2 million people currently registered to donate marrow, is only about 40 percent. 2 million cord donors, we would be able to transplant nearly everyone who needed 'said Pablo Rubinstein, an immunogeneticist at the New York Blood Center. He and Joanne Kurtzberg, of Duke, reported the experiment in this week's New England Journal of Medicine.
Cord blood, which is actually fetal blood the newborn no longer needs, appears to have two important qualities that make it good for transplantation. It is rich in progenitor cells that can a patient's ravaged blood system and then multiply a thousandfold to restore it. Further, because the cells come from a donor that (even at birth) is still developing, they have a much weaker sense of than marrow cells taken from an adult. That makes them much less likely to attack the body tissues of the person getting the transplant. The new research involved 25 patients, most of them children.
Most had some form of blood cancer, though four had non-malignant diseases that destroy bone marrow. About half the patients had unsuccessfully sought a marrow donor, and the rest were in such dire straits that they couldn't wait for one. A year after the experimental treatment, 12 of the 25 were alive, with apparently successful cord blood transplants. Thirteen had died. If the patients hadn't gotten the treatment, their probability of living one year was "about zero," Rubinstein said.
Before attempting a transplant whether of bone marrow or cord blood physicians determine the number of matches among six crucial genetic variables called HLA antigens. A six-out-of-six match between donor and recipient is optimal. A major advantage of the cord blood procedure is that it allows a greater mismatch than a bone marrow transplant with no loss of effectiveness. Of the 25 Duke patients, 21 had at least one mismatch. Four had three mismatches, and one of them is among the survivors.
In all but two patients, the transplant "took," though in some cases the patient died either from an infection or a relapse of disease. IN THE NATION Before leaving the witness New panel day stand of on a less testimony, acrimonious, Lindsey told second the trial of the bank's owners that to study eve of repayments when the a 1992 were nationwide presidential extended until fund-raising election the appeal retired them. gambling a testimony, The prelude to which questioning is Clinton's of expected Lindsey videotaped to was be WASHINGTON The Senate voted Wednesday to create a national commission to study the growth of legal gambling, giving the panel the power to subpoena financial and marketing records from the gaming industry. Over the past decade, gambling profits have swelled to $40 billion a year, with $482 billion legally wagered in 48 states. One industry survey found that more people visited casinos in 1994 than attended professional and college football arena concerts and the thegames, ater combined.
The nine-member commission is to spend two years examining the relationship between gambling and social problems like crime, addiction and lost work productivity. Associated Press Drummer fired after heroin charges NEW YORK Jimmy Chamberlin, the drummer for the rock Smashing Pumpkins who was group arrested last week in New York on drug possession charges, has been fired, the remaining band members said in a statement Wednesday. "Today we are very sorry to tell our friends and fans that we have decided to sever our relationship our friend and drummer Jimmy Chamberlin," the statement says. nine years we have battled with Jimmy's struggles with the insidious disease of drug and alcohol addiction. It has nearly destroyed everything we are and stand for.
We have decided to carry on without him, and we wish him the best that we have to offer." Chamberlin, 32, was arrested at a New York hotel and Friday charged with heroin possession after the band's backup keyboardist, Jonathan Melvoin, was found dead in a hotel room apparently of a heroin overdose. Melvoin was 34. The New York Times Aide says Clinton got payment delay LITTLE ROCK, Ark. Completing his Whitewater trial testimony, presidential aide Bruce Lindsey acknowledged Wednesday that an Arkansas bank allowed Bill Clinton of $100,000 in to delay repayment personal loans for two years. The Roanoke Times, Thursday, July 18, 1996 A 9 BA 000 That's not the tires that're squealing.
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